Alessandro was the fifth of nine Melani brothers who were all famous musicians (4 as castrato singers) in various European courts: 1. Jacopo (1623-1676), 2. Atto (1626-1714), 3. Francesco Maria (1628-1668?), 4. Bartolomeo (1634-?), 6. Antonio (16?-?), 7. Domenico (16?-?), 8. Nicola (16?-?), and Vincenzo (16?-?).
Alessandro Melani was choir master at Pistoia at the Church of San Petronio of Bologna (beginning 1660) and in Rome (from 1667 until his death in 1703). His prolific pen left us 4 operas, church music, oratorios, cantatas and canzoni.